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Title: Antiherpetic effects of Gynura procumbens
Authors: Siripen Jarikasem
Somyot Charuwichitratana
Sontana Siritantikorn
Wasan Chantratita
Magdy Iskander
August Wilhelm Frahm
Weena Jiratchariyakul
Mahidol University
Thailand Institute of Scientific and Technological Research (TISTR)
Faculty of Medicine, Siriraj Hospital, Mahidol University
Monash University Victorian College of Pharmacy
Universitat Freiburg im Breisgau
Keywords: Medicine
Issue Date: 18-Oct-2013
Citation: Evidence-based Complementary and Alternative Medicine. Vol.2013, (2013)
Abstract: The ethanol extract of Gynura procumbens showed virucidal and antireplicative actions against herpes simplex virus HSV-1 and HSV-2. It was further chromatographed on MCI gel CHP20P column giving the extract fractions F1 (water), F2 (water-methanol) F3 (methanol), and F4 (ethyl acetate). All but F1 had virucidal action against both viral types. We reported here the active compounds from F2 and F3. The antiherpetic compounds of F2 was a mixture of dicaffeoylquinic acids with virucidal and antireplicative actions against HSV-2 (IC96.0 and 61.0 g/mL, resp.) Virucidal compounds of F3 were a mixture of β-sitosterol and stigmasterol (IC250.0 g/mL against HSV-1), a mixture of β-sitosteryl and stigmasteryl glucosides (IC50.0 g/mL against HSV-2) and 1, 2-bis-dodecanoyl-3-α-D-glucopyranosyl-sn-glycerol (ICof 40.0 g/mL against HSV-2). Herbal products containing 1 and 2% of standardized ethanol extract were prepared. Double-blind randomized controlled clinical trial of the products was performed in patients with recurrent herpes labialis. Results showed that the number of patients, whose lesions healed within 7 days and the average healing time of both groups differed insignificantly. Viral culture on D7 indicated a decrease of infected patients from 48.7% to 7.69% in treated group whereas in placebo group the infected patients decreased from 31.25% to 20.00%. The viral reduction in treated group indicated the benefit of the product. Insignificant result might arise from a low number of participated patients and insufficient concentration of plant extract in herbal product. © 2013 Siripen Jarikasem et al.
ISSN: 17414288
Appears in Collections:Scopus 2011-2015

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