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dc.contributor.authorSiripen Jarikasemen_US
dc.contributor.authorSomyot Charuwichitratanaen_US
dc.contributor.authorSontana Siritantikornen_US
dc.contributor.authorWasan Chantratitaen_US
dc.contributor.authorMagdy Iskanderen_US
dc.contributor.authorAugust Wilhelm Frahmen_US
dc.contributor.authorWeena Jiratchariyakulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand Institute of Scientific and Technological Research (TISTR)en_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherMonash University Victorian College of Pharmacyen_US
dc.contributor.otherUniversitat Freiburg im Breisgauen_US
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. Vol.2013, (2013)en_US
dc.description.abstractThe ethanol extract of Gynura procumbens showed virucidal and antireplicative actions against herpes simplex virus HSV-1 and HSV-2. It was further chromatographed on MCI gel CHP20P column giving the extract fractions F1 (water), F2 (water-methanol) F3 (methanol), and F4 (ethyl acetate). All but F1 had virucidal action against both viral types. We reported here the active compounds from F2 and F3. The antiherpetic compounds of F2 was a mixture of dicaffeoylquinic acids with virucidal and antireplicative actions against HSV-2 (IC96.0 and 61.0 g/mL, resp.) Virucidal compounds of F3 were a mixture of β-sitosterol and stigmasterol (IC250.0 g/mL against HSV-1), a mixture of β-sitosteryl and stigmasteryl glucosides (IC50.0 g/mL against HSV-2) and 1, 2-bis-dodecanoyl-3-α-D-glucopyranosyl-sn-glycerol (ICof 40.0 g/mL against HSV-2). Herbal products containing 1 and 2% of standardized ethanol extract were prepared. Double-blind randomized controlled clinical trial of the products was performed in patients with recurrent herpes labialis. Results showed that the number of patients, whose lesions healed within 7 days and the average healing time of both groups differed insignificantly. Viral culture on D7 indicated a decrease of infected patients from 48.7% to 7.69% in treated group whereas in placebo group the infected patients decreased from 31.25% to 20.00%. The viral reduction in treated group indicated the benefit of the product. Insignificant result might arise from a low number of participated patients and insufficient concentration of plant extract in herbal product. © 2013 Siripen Jarikasem et al.en_US
dc.rightsMahidol Universityen_US
dc.titleAntiherpetic effects of Gynura procumbensen_US
Appears in Collections:Scopus 2011-2015

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