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Title: Small-dense LDL cholesterol/large-buoyant LDL cholesterol ratio as an excellent marker for indicating lipodystrophy in HIV-infected patients
Authors: Pornpen Srisawasdi
Tanida Suwalak
Chonlaphat Sukasem
Anchalee Chittamma
Anothai Pocathikorn
Somlak Vanavanan
Apichaya Puangpetch
Siwalee Santon
Wasun Chantratita
Sasisopin Kiertiburanakul
Martin H. Kroll
Mahidol University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Prince of Songkla University
Quest Diagnostics
Keywords: Medicine
Issue Date: 1-Oct-2013
Citation: American Journal of Clinical Pathology. Vol.140, No.4 (2013), 506-515
Abstract: Objectives: To examine whether the lipid parameters are predicting factors for human immunodeficiency virus (HIV)- associated lipodystrophy. Methods: Whole-body fat compositions of HIV-positive patients receiving stavudine-containing antiretroviral regimens (n = 79) were determined. Lipodystrophy was defined as a ratio of trunk fat mass/lower limb fat mass greater than 2.28. Blood samples were analyzed for total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), small-dense LDL-C (sdLDL-C), apoAI, apoB, lipoprotein(a), and CD4 cell counts. Large-buoyant LDL-C (lbLDL-C) was calculated (LDL-C minus sdLDL-C). Results: Twenty-six patients were classified as having lipodystrophy. The mean values of triglycerides, HDL-C, sdLDL-C, apoB, TC/HDL-C, apolipoprotein (apo) B/apoAI, and sdLDL-C/lbLDL-C showed significant differences between patients with and without lipodystrophy (P < .02). Using logistic regression analysis, sdLDL-C/lbLDL-C was identified as a significant predictor of lipodystrophy (P < .001). At a ratio of 0.554, the odds ratio was 17.8 with a likelihood ratio of 5.5. Conclusions: The sdLDL-C/lbLDL-C ratio is an excellent marker for indicating lipodystrophy in HIV-infected patients. © American Society for Clinical Pathology.
ISSN: 19437722
Appears in Collections:Scopus 2011-2015

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