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Title: Risk factors of breast cancer: A systematic review and meta-analysis
Authors: Thunyarat Anothaisintawee
Cholatip Wiratkapun
Panuwat Lerdsitthichai
Vijj Kasamesup
Sansanee Wongwaisayawan
Jiraporn Srinakarin
Siriporn Hirunpat
Piyanoot Woodtichartpreecha
Sarawan Boonlikit
Yot Teerawattananon
Ammarin Thakkinstian
Mahidol University
Khon Kaen University
Prince of Songkla University
National Cancer Institute Thailand
Thailand Ministry of Public Health
Keywords: Medicine
Issue Date: 1-Sep-2013
Citation: Asia-Pacific Journal of Public Health. Vol.25, No.5 (2013), 368-387
Abstract: The etiology of breast cancer might be explained by 2 mechanisms, namely, differentiation and proliferation of breast epithelial cells mediated by hormonal factors. We performed a systematic review and meta-analysis to update effects of risk factors for both mechanisms. MEDLINE and EMBASE were searched up to January 2011. Studies that assessed association between oral contraceptives (OC), hormonal replacement therapy (HRT), diabetes mellitus (DM), or breastfeeding and breast cancer were eligible. Relative risks with their confidence intervals (CIs) were extracted. A random-effects method was applied for pooling the effect size. The pooled odds ratios of OC, HRT, and DM were 1.10 (95% CI = 1.03-1.18), 1.23 (95% CI = 1.21-1.25), and 1.14 (95% CI = 1.09-1.19), respectively, whereas the pooled odds ratio of ever-breastfeeding was 0.72 (95% CI = 0.58-0.89). Our study suggests that OC, HRT, and DM might increase risks, whereas breastfeeding might lower risks of breast cancer. © 2013 APJPH.
ISSN: 10105395
Appears in Collections:Scopus 2011-2015

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