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dc.contributor.authorThunyarat Anothaisintaweeen_US
dc.contributor.authorCholatip Wiratkapunen_US
dc.contributor.authorPanuwat Lerdsitthichaien_US
dc.contributor.authorVijj Kasamesupen_US
dc.contributor.authorSansanee Wongwaisayawanen_US
dc.contributor.authorJiraporn Srinakarinen_US
dc.contributor.authorSiriporn Hirunpaten_US
dc.contributor.authorPiyanoot Woodtichartpreechaen_US
dc.contributor.authorSarawan Boonlikiten_US
dc.contributor.authorYot Teerawattananonen_US
dc.contributor.authorAmmarin Thakkinstianen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.contributor.otherNational Cancer Institute Thailanden_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.identifier.citationAsia-Pacific Journal of Public Health. Vol.25, No.5 (2013), 368-387en_US
dc.description.abstractThe etiology of breast cancer might be explained by 2 mechanisms, namely, differentiation and proliferation of breast epithelial cells mediated by hormonal factors. We performed a systematic review and meta-analysis to update effects of risk factors for both mechanisms. MEDLINE and EMBASE were searched up to January 2011. Studies that assessed association between oral contraceptives (OC), hormonal replacement therapy (HRT), diabetes mellitus (DM), or breastfeeding and breast cancer were eligible. Relative risks with their confidence intervals (CIs) were extracted. A random-effects method was applied for pooling the effect size. The pooled odds ratios of OC, HRT, and DM were 1.10 (95% CI = 1.03-1.18), 1.23 (95% CI = 1.21-1.25), and 1.14 (95% CI = 1.09-1.19), respectively, whereas the pooled odds ratio of ever-breastfeeding was 0.72 (95% CI = 0.58-0.89). Our study suggests that OC, HRT, and DM might increase risks, whereas breastfeeding might lower risks of breast cancer. © 2013 APJPH.en_US
dc.rightsMahidol Universityen_US
dc.titleRisk factors of breast cancer: A systematic review and meta-analysisen_US
Appears in Collections:Scopus 2011-2015

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