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dc.contributor.authorNicholas M. Douglasen_US
dc.contributor.authorJulie A. Simpsonen_US
dc.contributor.authorAung Pyae Phyoen_US
dc.contributor.authorHadjar Siswantoroen_US
dc.contributor.authorArmedy R. Hasugianen_US
dc.contributor.authorEnny Kenangalemen_US
dc.contributor.authorJeanne Rini Poespoprodjoen_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.authorNicholas M. Ansteyen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorEmiliana Tjitraen_US
dc.contributor.authorFrancois Nostenen_US
dc.contributor.authorRic N. Priceen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherBadan Penelitian Dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesiaen_US
dc.contributor.otherMimika District Health Authorityen_US
dc.contributor.otherNational Institutes of Health, Bethesdaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRoyal Darwin Hospitalen_US
dc.date.accessioned2018-10-19T05:17:59Z-
dc.date.available2018-10-19T05:17:59Z-
dc.date.issued2013-09-01en_US
dc.identifier.citationJournal of Infectious Diseases. Vol.208, No.5 (2013), 801-812en_US
dc.identifier.issn00221899en_US
dc.identifier.other2-s2.0-84881649097en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84881649097&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/32196-
dc.description.abstractBackground. Designing interventions that will reduce transmission of vivax malaria requires knowledge of Plasmodium vivax gametocyte dynamics.Methods. We analyzed data from a randomized controlled trial in northwestern Thailand and 2 trials in Papua, Indonesia, to identify and compare risk factors for vivax gametocytemia at enrollment and following treatment.Results. A total of 492 patients with P. vivax infections from Thailand and 476 patients (162 with concurrent falciparum parasitemia) from Indonesia were evaluable. Also, 84.3% (415/492) and 66.6% (209/314) of patients with monoinfection were gametocytemic at enrollment, respectively. The ratio of gametocytemia to asexual parasitemia did not differ between acute and recurrent infections (P =. 48 in Thailand, P =. 08 in Indonesia). High asexual parasitemia was associated with an increased risk of gametocytemia during follow-up in both locations. In Thailand, the cumulative incidence of gametocytemia between day 7 and day 42 following dihydroartemisinin + piperaquine (DHA + PIP) was 6.92% vs 29.1% following chloroquine (P <. 001). In Indonesia, the incidence of gametocytemia was 33.6% following artesunate + amodiaquine (AS + AQ), 7.42% following artemether + lumefantrine, and 6.80% following DHA + PIP (P <. 001 for DHA + PIP vs AS + AQ).Conclusions. P. vivax gametocyte carriage mirrors asexual-stage infection. Prevention of relapses, particularly in those with high asexual parasitemia, is likely the most important strategy for interrupting P. vivax transmission. © 2013 The Author.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84881649097&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleGametocyte dynamics and the role of drugs in reducing the transmission potential of plasmodium vivaxen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1093/infdis/jit261en_US
Appears in Collections:Scopus 2011-2015

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