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dc.contributor.authorKanchana Kengkoomen_US
dc.contributor.authorAekkarin Klinkhamhomen_US
dc.contributor.authorAunchalee Sirimontapornen_US
dc.contributor.authorOrnuma Singhaen_US
dc.contributor.authorTaweesak Ketjareonen_US
dc.contributor.authorYaowaluk Panavechkijkulen_US
dc.contributor.authorDutmanee Seriwatanachaien_US
dc.contributor.authorSuluck Ukongen_US
dc.contributor.authorSumate Ampawongen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherSilpakorn Universityen_US
dc.identifier.citationInternational Journal of Clinical and Experimental Pathology. Vol.6, No.4 (2013), 639-649en_US
dc.description.abstractTo understand the relationship among cholesterolemia, hyperglycemic stage in non obese type 2 diabetes mellitus, and histological perturbations on liver, retina, hippocampus, and Harderian gland, we maintained rat on a diet high in cholesterol for fourteen weeks, then analyzed blood lipid profiles, blood glucose, hepatic enzymes, and microscopic lesion of those tissues. We observed that high cholesterol-treated rat elevated in cholesterol and low density lipoprotein with not correlated to hyperglycemia. Histopathological changing in Goto-Kakizaki rat on liver (microvesicular steatosis) and Harderain gland (tubular lesions) were related to hyperglycemic effect rather than cholesterolemic effect. These may be related to hypoinsulinemic characteristic of this diabetic model. However increasing pyknotic nuclei on hippocampus and reducing of retinal ganglionic cell were related to the high level of cholesterol loaded with synergized effect due to diabetic stage.en_US
dc.rightsMahidol Universityen_US
dc.titleEffects on high cholesterol-fed to liver, retina, hippocampus, and harderian gland in goto-kakizaki raten_US
Appears in Collections:Scopus 2011-2015

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