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Title: Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma
Authors: Pasra Arnutti
Manas Kotepui
Wichitra Asanprakit
Phaibul Punyarit
Porntip Chavalitshewinkoon-Petmitr
Talabporn Harnroongroj
Songsak Petmitr
Mahidol University
Phramongkutklao College of Medicine
Army Institute of Pathology
Keywords: Medicine
Issue Date: 30-Aug-2013
Citation: International Journal of Clinical and Experimental Pathology. Vol.6, No.6 (2013), 1112-1120
Abstract: Breast cancer is the most common cancer affecting women worldwide including Thailand. Whole transcription profiles of invasive ductal breast carcinoma (IDC) obtained by oligonucleotide microarray should lead to a better understanding of the molecular basis of IDCs, allow for examination of specific markers for diagnosis, and provide novel targets for therapy. This study aimed to detect the whole transcript expression of approximately 35,000 target genes in Thai breast cancer patients, using Affymetrix GeneChip® Exon 1.0 Sense Target Arrays. Analysis revealed that the differential expression profiles of 928 genes (423 up-regulated and 505 down-regulated genes) were 2-fold or greater (unpaired t-test, p < 0.05) in invasive ductal breast cancer, compared with normal tissues. The Gene Ontology (GO) databases support important associations in 17 gene sets with p-value < 1E-10 and ≥ 4-fold changes, involving the tumorigenic pathways of cell cycles, extracellular regions, as well as cellular component organization. Likewise, the TGFBR and IL-6 pathways contain gene expression with statistically significant changes in IDC.
ISSN: 19362625
Appears in Collections:Scopus 2011-2015

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