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dc.contributor.authorPasra Arnuttien_US
dc.contributor.authorManas Kotepuien_US
dc.contributor.authorWichitra Asanprakiten_US
dc.contributor.authorPhaibul Punyariten_US
dc.contributor.authorPorntip Chavalitshewinkoon-Petmitren_US
dc.contributor.authorTalabporn Harnroongrojen_US
dc.contributor.authorSongsak Petmitren_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPhramongkutklao College of Medicineen_US
dc.contributor.otherArmy Institute of Pathologyen_US
dc.identifier.citationInternational Journal of Clinical and Experimental Pathology. Vol.6, No.6 (2013), 1112-1120en_US
dc.description.abstractBreast cancer is the most common cancer affecting women worldwide including Thailand. Whole transcription profiles of invasive ductal breast carcinoma (IDC) obtained by oligonucleotide microarray should lead to a better understanding of the molecular basis of IDCs, allow for examination of specific markers for diagnosis, and provide novel targets for therapy. This study aimed to detect the whole transcript expression of approximately 35,000 target genes in Thai breast cancer patients, using Affymetrix GeneChip® Exon 1.0 Sense Target Arrays. Analysis revealed that the differential expression profiles of 928 genes (423 up-regulated and 505 down-regulated genes) were 2-fold or greater (unpaired t-test, p < 0.05) in invasive ductal breast cancer, compared with normal tissues. The Gene Ontology (GO) databases support important associations in 17 gene sets with p-value < 1E-10 and ≥ 4-fold changes, involving the tumorigenic pathways of cell cycles, extracellular regions, as well as cellular component organization. Likewise, the TGFBR and IL-6 pathways contain gene expression with statistically significant changes in IDC.en_US
dc.rightsMahidol Universityen_US
dc.titleDetermination of whole transcription profiles and specific pathways in invasive ductal breast carcinomaen_US
Appears in Collections:Scopus 2011-2015

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