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Title: Value of diffusion tensor imaging in differentiating high-grade from low-grade gliomas
Authors: Siriwan Piyapittayanan
Orasa Chawalparit
Siri On Tritakarn
Theerapol Witthiwej
Tumtip Sangruchi
Sarun Nunta-Aree
Sith Sathornsumetee
Parunut Itthimethin
Chulaluk Komoltri
Mahidol University
Keywords: Medicine
Issue Date: 13-Jun-2013
Citation: Journal of the Medical Association of Thailand. Vol.96, No.6 (2013), 716-721
Abstract: Objective: To determine the usefulness of diffusion tensor imaging (DTI) in differentiating high-grade glioma (HGG) from low-grade glioma (LGG). Material and Method: Patients with cerebral gliomas underwent conventional MRI and DTI before surgery. All proven pathologies were classified into two groups, i.e. LGG and HGG. The authors measured fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in region of interest (ROI) including solid tumoral region, necrotic region, peritumoral edema, contralateral normal appearing white matter (NAWM) and normal corpus callosum as well as calculated ADC ratios. Pairwise comparisons were performed by using the t-test. The ROC curves of imaging parameters were employed to determine the best parameter for differentiating the two entities. Results: Forty-three patients with cerebral gliomas, 17 with LGG and 26 with HGG, no statistical significant difference between LGG and HGG using mean FA values in each ROI. The ADC and minimal ADC values of solid tumoral region and peritumoral edema, the ADC and minimal ADC ratios of solid tumoral region are statistical significant to differentiate HGG from LGG, p<0.05. The ratio ADC solid tumoral region to normal corpus callosum had highest predictive accuracy to differentiate the two entities with AUC of 0.74. Conclusion: The ADC value, minimal ADC value, and ADC ratios of solid tumoral region appeared to be useful for differentiating HGG from LGG.
ISSN: 01252208
Appears in Collections:Scopus 2011-2015

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