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Title: Recurrent macrophage activation syndrome as the primary manifestation in systemic lupus erythematosus and the benefit of serial ferritin measurements: A case-based review
Authors: Soamarat Vilaiyuk
Nongnuch Sirachainan
Suthep Wanitkun
Kwanchai Pirojsakul
Jarin Vaewpanich
Mahidol University
Keywords: Medicine
Issue Date: 1-Jun-2013
Citation: Clinical Rheumatology. Vol.32, No.6 (2013), 899-904
Abstract: Macrophage activation syndrome (MAS) is a fatal complication in rheumatic diseases. It is characterized by prolonged fever, pancytopenia, and hepatosplenomegaly, which are consequences of uncontrolled macrophage activation. MAS in children is most commonly associated with systemic juvenile idiopathic arthritis. Its association with systemic lupus erythematosus (SLE) is relatively rare, so we report a Thai boy who initially presented with MAS and eventually was diagnosed as having SLE. He also had recurrent MAS during the course of therapy. Hyperferritinemia is one of the abnormal laboratory findings in MAS and it has been used as an inflammatory marker. However, its correlation with disease activity remains unclear. Therefore, a review of literature regarding MAS-associated SLE in children and ferritin level in this disease was carried out. © 2013 Clinical Rheumatology.
ISSN: 14349949
Appears in Collections:Scopus 2011-2015

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