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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/32369
Title: Long-term effectiveness of acetazolamide on permanent weakness in hyperkalemic periodic paralysis
Authors: Charungthai Dejthevaporn
Chutima Papsing
Bunyong Phakdeekitcharoen
Suphaneewan Jaovisidha
Suchart Phudhichareonrat
Rawiphan Witoonpanich
Teeratorn Pulkes
Mahidol University
Prasat Neurological Institute
Keywords: Medicine;Neuroscience
Issue Date: 1-May-2013
Citation: Neuromuscular Disorders. Vol.23, No.5 (2013), 445-449
Abstract: Acetazolamide is commonly used as an empirical treatment for inherited periodic paralyses although some patients may develop deleterious effects. We report a 65. year-old man with hyperkalemic periodic paralysis and late-onset permanent weakness in association with the common T704M mutation in α-subunit, skeletal muscle voltage-gated sodium channel gene. He rapidly recovered from weakness after acetazolamide treatment. Magnetic resonance imaging of thighs comparing pre- and post-treatment revealed a significant increase in muscle bulk. The patient has been without any type of weakness for over 6. years. This data show the remarkable benefit of acetazolamide on permanent weakness of hyperkalemic periodic paralysis in association with the T704M mutation. © 2013 Elsevier B.V.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876096599&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/32369
ISSN: 18732364
09608966
Appears in Collections:Scopus 2011-2015

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