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Title: Intestinal mucosal defense system, Part 2. Probiotics and prebiotics
Authors: Teresa Murguía-Peniche
Walter A. Mihatsch
Jaime Zegarra
Sarayut Supapannachart
Zong Yi Ding
Josef Neu
National Center for Child and Adolescent Health (CeNSIA)
Municipal Hospital Munich
Hospital Nacional Cayetano Heredia
Mahidol University
General Hospital of People's Liberation Army
University of Florida
Keywords: Medicine
Issue Date: 2-Apr-2013
Citation: Journal of Pediatrics. Vol.162, No.3 SUPPL. (2013)
Abstract: The interplay between microorganisms and the intestine of newborn infants is associated with diverse functional and clinical outcomes that result from the specific interactions among microbial communities, their products, and the unique characteristics of the gastrointestinal tract. Multiple mechanisms of action for infant formula ingredients with probiotic activity appear to exist. These mechanisms are thought to protect the host not only from intestinal diseases but also from systemic infection. However, questions about the safety of probiotics for preterm infants remain unanswered, particularly with regard to sepsis, immunomodulatory effects, and microbial resistance. Few well-designed studies have been conducted to evaluate the effects of probiotic, prebiotic, and synbiotic ingredients on relevant clinical outcomes in preterm infants. Although existing data are encouraging, there is insufficient evidence to recommend the routine use of these ingredients in all preterm infants.
ISSN: 10976833
Appears in Collections:Scopus 2011-2015

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