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dc.contributor.authorHenrike Westervelden_US
dc.contributor.authorRichard Pötteren_US
dc.contributor.authorDaniel Bergeren_US
dc.contributor.authorPittaya Dankulchaien_US
dc.contributor.authorWolfgang Dörren_US
dc.contributor.authorMircea Constantin Soraen_US
dc.contributor.authorSarah Pötter-Langen_US
dc.contributor.authorChristian Kirisitsen_US
dc.contributor.otherMedizinische Universitat Wienen_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationRadiotherapy and Oncology. Vol.107, No.1 (2013), 99-105en_US
dc.description.abstractAbstractBackground and purpose Traditionally, vaginal dose points have been defined at the vaginal source level, thus not providing dose information for the entire vagina. Since reliable vaginal dose volume/surface histograms are unavailable, a strategy for comprehensive vaginal dose reporting for combined EBRT and BT was established and investigated. Material and methods An anatomical vaginal reference point was defined at the level of the Posterior-Inferior Border of Symphysis (PIBS), plus two points ±2 cm (mid/introitus vagina). For BT extra points were selected for the upper vagina at 12/3/6/9 o'clock, at the vaginal surface and 5 mm depth. A vaginal reference length (VRL) was defined from ring centre to PIBS. Fifty-nine patients treated for cervical cancer were included in this retrospective feasibility study. Results The method was applicable to all patients. Total EQD2 doses at PIBS and ±2 cm were 36.7 Gy (3.1-68.2), 49.6 Gy (32.1-89.6) and 4.3 Gy (1.0-46.6). At the vaginal surface at ring level doses were respectively 266.1 Gy (67.6-814.5)/225.9 Gy (61.5-610.5) at 3/9 o'clock, and 85.1 Gy (55.4-140.3)/72.0 Gy (49.1-108.9) at 12/6 o'clock. Mean VRL on MRI was 5.6 cm (2.0-9.4). Conclusions With this novel system, a comprehensive reporting of vaginal doses is feasible. The present study has demonstrated large dose variations between patients observed in all parts of the vagina, resulting from different contributions from EBRT and BT. © 2013 Elsevier Ireland Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.titleVaginal dose point reporting in cervical cancer patients treated with combined 2D/3D external beam radiotherapy and 2D/3D brachytherapyen_US
Appears in Collections:Scopus 2011-2015

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