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Title: Organophosphate urinary metabolite levels during pregnancy, delivery and postpartum in women living in agricultural areas in Thailand
Authors: Pornpimol Kongtip
Noppanun Nankongnab
Susan Woskie
Akkarat Phamonphon
Prapin Tharnpoophasiam
Kitsiluck Wilaiwan
Punnee Srasom
Mahidol University
University of Massachusetts Lowell
Paholpolpayuhasena Hospital
Amnatcharoen Hospital
Keywords: Medicine
Issue Date: 1-Jan-2013
Citation: Journal of Occupational Health. Vol.55, No.5 (2013), 367-375
Abstract: Prenatal exposure to organophosphate pesticides can lead to developmental neurotoxicity. A longitudinal birth cohort was established to investigate pesticide exposures from different agricultural activities. Maternal urinary organophosphate metabolites were measured at 28 weeks of pregnancy (n=86), delivery (n=67) and 2 months postpartum (n=51). Method: Subjects were interviewed with questionnaires about work, home and behavioral factors potentially associated with pesticide exposures, and spot urine samples were also collected. The urine samples were analyzed for dimethyl phosphate (DMP), diethyl phosphate (DEP), diethyl thiophosphate (DETP) and diethyl dithiophosphate (DEDTP), using gas chromatography-mass spectrometry. Results: The urinary DMP and dialkyl phosphate (DAP) concentrations at 28 weeks of pregnancy and delivery were not significantly different, but the DMP and DAP concentrations at 28 weeks of pregnancy and DAP concentrations at delivery were significantly different (p<0.05) from those at 2 months postpartum. The factors influencing the urinary DAP concentrations at 28 weeks of pregnancy included insecticide used in the home, living close to agricultural farmland, frequency of agricultural field visits during the first and second trimesters of pregnancies, occupation of subjects, pesticide used and other agricultural Postpartumactivities. Conclusions: The urinary organophosphate metabolites, DMP, DEP, DETP, DEDTP, total DEP and DAPs, at 28 weeks of pregnancy, delivery and 2 months postpartum fluctuated depending on their pesticide exposures both at home and in agricultural fields.
ISSN: 13489585
Appears in Collections:Scopus 2011-2015

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