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Title: A multicenter randomized clinical trial of one-rod etonogestrel and two-rod levonorgestrel contraceptive implants with nonrandomized copper-IUD controls: Methodology and insertion data
Authors: Olav Meirik
Vivian Brache
Kiriwat Orawan
Ndema Abu Habib
Johannes Schmidt
Nuriye Ortayli
Kelly Culwell
Emily Jackson
Moazzam Ali
Organisation Mondiale de la Sante
Instituto Chileno de Medicina Reproductiva
Mahidol University
Glaxosmithkline Biologicals S.A.
University of California, Davis
University of Southern California
Keywords: Medicine
Issue Date: 1-Jan-2013
Citation: Contraception. Vol.87, No.1 (2013), 113-120
Abstract: Background: Comparative data on etonogestrel and two-rod levonorgestrel contraceptive implants are lacking. Study Design: A multicenter, open, parallel-group trial with random allocation of implants was performed. For every second implant user, an age-matched woman choosing an intrauterine device (IUD) (TCu380A) was admitted. Methods and data on implant/IUD insertion and 6-week follow-up are reported. Results: A total of 2008 women were randomized to an implant, and 974 women were enrolled in the IUD group. Results from 997 etonogestrel implant users, 997 levonorgestrel implant users and 971 IUD users were analyzed. In the etonogestrel and levonorgestrel groups, respectively, mean insertion durations were 51 (SD 50.2) s and 88 (SD 60.8) s; complication rates at insertion were 0.8% and 0.2%; and at follow-up, 27.2% and 26.7% of women, respectively, had signs or symptoms at the insertion site. At follow-up within 6 weeks after insertion, all implants were in situ, while 2.1% of IUDs were expelled. Conclusion: Performance of etonogestrel and levonorgestrel implants at insertion and within the first 6 weeks is similar. Short-term (6 weeks) continuation rates appear higher for implants than TCu380A. © 2013 Elsevier Inc.
ISSN: 18790518
Appears in Collections:Scopus 2011-2015

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