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Title: Risk factors and pathogenic significance of bacteremic pneumonia in adult patients with community-acquired pneumococcal pneumonia
Authors: Cheol In Kang
Jae Hoon Song
So Hyun Kim
Doo Ryeon Chung
Kyong Ran Peck
Visanu Thamlikitkul
Hui Wang
Thomas Man Kit So
Po Ren Hsueh
Rohani Md Yasin
Celia C. Carlos
Pham Hung Van
Jennifer Perera
SungKyunKwan University, School of Medicine
Asia Pacific Foundation for Infectious Diseases (APFID)
Mahidol University
Peking Union Medical College
Princess Margaret Hospital Hong Kong
National Taiwan University Hospital
Institute for Medical Research Kuala Lumpur
University of Medicine and Pharmacy
University of Colombo
Peking University
SureCare Medical Centre
Keywords: Medicine
Issue Date: 1-Jan-2013
Citation: Journal of Infection. Vol.66, No.1 (2013), 34-40
Abstract: Objective: This study was performed to identify risk factors for the development of bacteremic pneumonia and to evaluate the impact of bacteremia on the outcome of pneumococcal pneumonia. Methods: Using a database from a surveillance study of community-acquired pneumococcal pneumonia, we compared data of the bacteremic group with that of the non-bacteremic group. Results: Among 981 adult patients with pneumococcal pneumonia, 114 (11.6%) patients who had documented pneumococcal bacteremia were classified into the bacteremic group. In a multivariable analysis, use of immunosuppressant drugs, younger age (<65 years), and DM were independent risk factors associated with the development of bacteremic pneumonia among patients with pneumococcal pneumonia (all P < 0.05). The mortality rate was significantly higher in the bacteremic group than in the non-bacteremic group (28.6% vs. 8.5%; P < 0.001). The multivariable analysis revealed that concomitant bacteremia was one of the significant risk factors associated with mortality (OR, 2.57; 95% CI, 1.24-5.29), along with cerebrovascular disease and presentation with septic shock (all P < 0.05). Conclusions: Bacteremia was a common finding in pneumococcal pneumonia and was associated with a higher mortality rate. Several clinical variables may be useful for predicting bacteremic pneumonia among patients with pneumococcal pneumonia. © 2012.
ISSN: 15322742
Appears in Collections:Scopus 2011-2015

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