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dc.contributor.authorS. Ngampramuanen_US
dc.contributor.authorM. Baumerten_US
dc.contributor.authorB. Czippelovaen_US
dc.contributor.authorE. Nalivaikoen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Adelaideen_US
dc.contributor.otherHunter Medical Research Institute, Australiaen_US
dc.contributor.otherComenius Universityen_US
dc.date.accessioned2018-10-19T05:41:01Z-
dc.date.available2018-10-19T05:41:01Z-
dc.date.issued2013-08-29en_US
dc.identifier.citationNeuroscience. Vol.246, (2013), 342-350en_US
dc.identifier.issn18737544en_US
dc.identifier.issn03064522en_US
dc.identifier.other2-s2.0-84878907881en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878907881&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/32712-
dc.description.abstractThere are a limited number of biological indices for assessing pro-emetic states in laboratory rodents as they do not possess the vomiting response. In the present study we tested the hypothesis that in rats, pro-emetic intervention would affect the respiratory pattern. To this end, using whole-body plethysmography, in adult male Wistar rats we recorded respiration after i.p. administration of either the emetic agent LiCl or Ringer. Quantification of respiratory signals (from 5 to 35min post-injection) revealed that post-LiCl, mean respiratory rate was significantly lower (126±9 vs. 178±10cpm, p<0.005) and less variable (Kvar59±8% vs. 73±3%; p<0.05) compared to the post-Ringer condition. Furthermore, while mode values of respiratory rate histograms did not differ between the treatments (indicating that the dominant respiratory frequency remained unchanged), LiCl reduced the fraction of time spent at high respiratory rate (>200cpm) from 25±3% to 9±2% (p=0.004). Thus, reduction of the mean respiratory rate by LiCl was predominantly due to reduced contribution of high-frequency breathing that is normally associated with motor activity and/or arousal. Non-linear multifractal analysis of respiratory signals revealed that post-LiCl, respiration becomes less random and more orderly. 5-HT3 antagonist ondansetron prevented respiratory changes elicited by LiCl. We conclude that the observed changes likely reflect effects of LiCl on animals' motion, and that this effect is mediated via 5-HT3 receptors. Providing that the effects observed in our study were quite robust, we suggest that simple and non-invasive respiratory monitoring may be a promising approach for studying emesis in rodents. © 2013 IBRO.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878907881&origin=inwarden_US
dc.subjectNeuroscienceen_US
dc.titleOndansetron prevents changes in respiratory pattern provoked by LiCl: A new approach for studying pro-emetic states in rodents?en_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.neuroscience.2013.05.012en_US
Appears in Collections:Scopus 2011-2015

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