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Title: Comparing interferon-gamma release assays to tuberculin skin test in thai children with tuberculosis exposure
Authors: Hong Van Tieu
Piyarat Suntarattiwong
Thanyawee Puthanakit
Tawee Chotpitayasunondh
Kulkanya Chokephaibulkit
Sunee Sirivichayakul
Supranee Buranapraditkun
Patcharawee Rungrojrat
Nitiya Chomchey
Simon Tsiouris
Scott Hammer
Vijay Nandi
Jintanat Ananworanich
New York Blood Center
Columbia University Medical Center
Queen Sirikit National Institute of Child Health
Chulalongkorn University
The HIV Netherlands Australia Thailand Research Collaboration
Mahidol University
Faculty of Medicine, Thammasat University
Walter Reed Army Institute of Research
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 14-Aug-2014
Citation: PLoS ONE. Vol.9, No.8 (2014)
Abstract: Background: Data on the performance of interferon-gamma release assays (IGRAs), QuantiFERON TB Gold In-tube (QFNGIT) and T-Spot.TB, in diagnosing tuberculosis (TB) are limited in Southeast Asia. This study aims to compare the performances of the two IGRAs and TST in Thai children with recent TB exposure. Methods: This multicenter, prospective study enrolled children with recent exposure to active TB adults. Children were investigated for active TB. TST was performed and blood collected for T-Spot.TB and QFNGIT. Results: 158 children were enrolled (87% TB-exposed and 13% active TB, mean age 7.2 years). Only 3 children had HIV infection. 66.7% had TST≥10 mm, while 38.6% had TST≥15 mm. 32.5% had positive QFNGIT; 29.9% had positive T-Spot.TB. QFNGIT and T-Spot.TB positivity was higher among children with active TB compared with TB-exposed children. No indeterminate IGRA results were detected. No statistically significant differences between the performances of the IGRAs and TST at the two cut-offs with increasing TB exposure were detected. Concordance for positive IGRAs and TST ranged from 42-46% for TST≥10 mm and 62-67% for TST≥15 mm. On multivariable analyses, exposure to household primary/secondary caregiver with TB was associated with positive QFNGIT. Higher TB contact score and active TB were associated with positive T-Spot.TB. Conclusions: Both QFNGIT and T-Spot.TB performed well in our Thai pediatric study population. No differences in the performances between tests with increasing TB exposure were found. Due to accessibility and low cost, using TST may more ideal than IGRAs in diagnosing latent and active TB in healthy children in Thailand and other similar settings. © 2014 Tieu et al.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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