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Title: Etiologies and resistance profiles of bacterial community-acquired pneumonia in cambodian and neighboring countries' health care settings: A systematic review (1995 to 2012)
Authors: Sophie Goyet
Erika Vlieghe
Varun Kumar
Steven Newell
Catrin E. Moore
Rachel Bousfield
Heng C. Leang
Sokheng Chuop
Phe Thong
Blandine Rammaert
Sopheak Hem
Johan Van Griensven
Agus Rachmat
Thomas Fassier
Kruy Lim
Arnaud Tarantola
Institut Pasteur du Cambodge
Prins Leopold Instituut voor Tropische Geneeskunde
Angkor Hospital for Children
Naval Medical Research Unit-2
Mahidol University
University of Oxford
National Institute of Public Health
Sihanouk Hospital Center of HOPE
Hopital Necker Enfants Malades
University of Health Sciences
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 13-Mar-2014
Citation: PLoS ONE. Vol.9, No.3 (2014)
Abstract: Objectives: Community-acquired pneumonia (CAP) is one of the most important causes of morbidity and mortality worldwide. Etiological data for Cambodia is scarce. We aimed to describe the main etiological agents causing CAP, and their resistance patterns in Cambodia and the greater Mekong region. Methods: A review of bacterial etiologies of CAP and antimicrobial resistance in Cambodia and neighboring countries was conducted via: (1) a systematic review of published literature in all NCBI databases using Pubmed, Google scholar, EMBASE, the World Health Organization and the Cambodian Ministry of Health libraries; (2) a review of unpublished data from Cambodia provided by national and international stakeholders working at different tiers of the healthcare system. Results: Twenty three articles and five data sources reported etiologies for 5919 CAP patients diagnosed between May 1995 and December 2012, including 1421 (24.0%), 3571 (60.3%) and 927 (15.7%) from Cambodia, Thailand and Vietnam, respectively. Streptococcus pneumoniae and Haemophilus influenzae were the most common pathogens ranking among the five most prevalent in 12 and 10 studies, respectively. Gram-negative bacteria such as Burkholderia pseudomallei and Klebsiella pneumoniae were also frequently diagnosed, particularly in bacteremic CAP in Thai adults and Cambodian children. In Thailand and Vietnam, Mycoplasma pneumoniae and Chlamydia pneumoniae were frequently identified in settings using indirect laboratory testing. Conclusions: Based on this analysis, CAP data in Cambodia seems to present etiological and resistance profiles comparable to those of neighboring countries. Findings have been shared with the national authorities upon the revision of the national therapeutic guidelines and were disseminated using a specially created website. © 2014 Goyet et al.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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