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Title: Cytotoxic sesquiterpenoids and diarylheptanoids from the rhizomes of Curcuma elata Roxb.
Authors: Ratchanaporn Chokchaisiri
Prapapan Pimkaew
Pawinee Piyachaturawat
Rattana Chalermglin
Apichart Suksamrarn
Ramkhamhaeng University
University of Phayao
Mahidol University
Chandrakasem Rajabhat University
Keywords: Agricultural and Biological Sciences;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2014
Citation: Records of Natural Products. Vol.8, No.1 (2014), 46-50
Abstract: The present study was aimed to investigate the chemical constituents of Curcuma elata Roxb. (Zingiberaceae) rhizomes originating in Thailand. Ten sesquiterpenes, germacrone (1), curzerenone (2), isofuranodienone (3), furanodienone (4), curdione (5), neocurdione (6), zederone (7), curcumenone (8), 13-hydroxygermacrone (9) and zedoarondiol (10), and four diarylheptanoids, 3-hydroxy-5-platyphyllone (11), (3S)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol (12), centrolobol (13) and (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-(6E)-6-hepten-3-ol (14) were isolated for the first time from the rhizomes of this plant. The structures of the isolated compounds were identified by comparison of the spectroscopic and physical data with those of the reported values and the stereochemistry at the asymmetric carbon was determined by the modified Mosher's method and, in some cases, was confirmed by comparison of optical rotation data with literature. Compounds 12 and 13 exhibited strong cytotoxic activity against KB cell line, whereas compounds 4, 9 and 12-14 showed strong cytoxicity against NCI-H187 cell line. © 2014 ACG Publications. All rights reserved.
ISSN: 13076167
Appears in Collections:Scopus 2011-2015

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