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Title: Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense
Authors: Sakchai Hongthong
Chutima Kuhakarn
Vichai Reutrakul
Surawat Jariyawat
Pawinee Piyachaturawat
Narong Nuntasaen
Thaworn Jaipetch
Mahidol University
National Park, Wildlife and Plant Conservation Department, Thailand
Keywords: Agricultural and Biological Sciences;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2014
Citation: Natural Product Communications. Vol.9, No.7 (2014), 929-932
Abstract: Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.
ISSN: 15559475
Appears in Collections:Scopus 2011-2015

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