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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33159
Title: Differentiation-inducing effect of piperitenone oxide, a fragrant ingredient of spearmint (Mentha spicata), but not carvone and menthol, against human colon cancer cells
Authors: Yasushi Nakamura
Yuki Hasegawa
Koji Shirota
Noboru Suetome
Takako Nakamura
Mullika Traidej Chomnawang
Krit Thirapanmethee
Piyatip Khuntayaporn
Panida Boonyaritthongchai
Chalermchai Wongs-Aree
Shigehisa Okamoto
Tomoaki Shigeta
Tomoaki Matsuo
Eun Young Park
Kenji Sato
Kyoto Prefectural University
Forestry and Fisheries Technology Center
Mahidol University
King Mongkuts University of Technology Thonburi
Kagoshima University
Keywords: Agricultural and Biological Sciences;Medicine;Nursing
Issue Date: 1-Jan-2014
Citation: Journal of Functional Foods. Vol.8, No.1 (2014), 62-67
Abstract: The n-hexane extract from spearmint (Mentha spicata) leaves was purified via a bioassay-guided fractionation scheme, which was based on the induction of differentiation in a RCM-1 human colon cancer cell line. One of the criteria of a differentiation marker is the formation of ducts determined visually using phase contrast microscopy, the most potent fraction contained piperitenone oxide, based on EI-MS, 1H-NMR and 13C-NMR spectra. Previously, the role of piperitenone oxide was considered as an odor producing compound in spearmint cultivars, but this study indicates the potential medical benefits of this compound. The effective dose of piperitenone oxide was lower than that of any differentiation-inducers found in the bioassay. Piperitenone oxide was categorized into monoterpene such as carvone and menthol, which are also familiar ingredients in Mentha genus plants. However, carvone and menthol did not possess the differentiation-inducing effect. © 2014 Elsevier Ltd.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899956446&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/33159
ISSN: 17564646
Appears in Collections:Scopus 2011-2015

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