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Title: | HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities |
Authors: | Justin Pollara Mattia Bonsignori M. Anthony Moody Pinghuang Liu S. Munir Alam Kwan Ki Hwang Thaddeus C. Gurley Daniel M. Kozink Lawrence C. Armand Dawn J. Marshall John F. Whitesides Jaranit Kaewkungwal Sorachai Nitayaphan Punnee Pitisuttithum Supachai Rerks-Ngarm Merlin L. Robb Robert J. O'Connell Jerome H. Kim Nelson L. Michael David C. Montefiori Georgia D. Tomaras Hua Xin Liao Barton F. Haynes Guido Ferrari Duke University Medical Center Mahidol University Armed Forces Research Institute of Medical Sciences, Thailand Thailand Ministry of Public Health US Military HIV Research Program |
Keywords: | Agricultural and Biological Sciences;Immunology and Microbiology |
Issue Date: | 1-Jan-2014 |
Citation: | Journal of Virology. Vol.88, No.14 (2014), 7715-7726 |
Abstract: | The RV144 ALVAC/AIDSVax HIV-1 vaccine clinical trial showed an estimated vaccine efficacy of 31.2%. Viral genetic analysis identified a vaccine-induced site of immune pressure in the HIV-1 envelope (Env) variable region 2 (V2) focused on residue 169, which is included in the epitope recognized by vaccinee-derived V2 monoclonal antibodies. The ALVAC/AIDSVax vaccine induced antibody-dependent cellular cytotoxicity (ADCC) against the Env V2 and constant 1 (C1) regions. In the presence of low IgA Env antibody levels, plasma levels of ADCC activity correlated with lower risk of infection. In this study, we demonstrate that C1 and V2 monoclonal antibodies isolated from RV144 vaccinees synergized for neutralization, infectious virus capture, and ADCC. Importantly, synergy increased the HIV-1 ADCC activity of V2 monoclonal antibody CH58 at concentrations similar to that observed in plasma of RV144 vaccinees. These findings raise the hypothesis that synergy among vaccine-induced antibodies with different epitope specificities contributes to HIV-1 antiviral antibody responses and is important to induce for reduction in the risk of HIV-1 transmission. © 2014, American Society for Microbiology. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904113226&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/33160 |
ISSN: | 10985514 0022538X |
Appears in Collections: | Scopus 2011-2015 |
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