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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33160
Title: HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities
Authors: Justin Pollara
Mattia Bonsignori
M. Anthony Moody
Pinghuang Liu
S. Munir Alam
Kwan Ki Hwang
Thaddeus C. Gurley
Daniel M. Kozink
Lawrence C. Armand
Dawn J. Marshall
John F. Whitesides
Jaranit Kaewkungwal
Sorachai Nitayaphan
Punnee Pitisuttithum
Supachai Rerks-Ngarm
Merlin L. Robb
Robert J. O'Connell
Jerome H. Kim
Nelson L. Michael
David C. Montefiori
Georgia D. Tomaras
Hua Xin Liao
Barton F. Haynes
Guido Ferrari
Duke University Medical Center
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand Ministry of Public Health
US Military HIV Research Program
Keywords: Agricultural and Biological Sciences;Immunology and Microbiology
Issue Date: 1-Jan-2014
Citation: Journal of Virology. Vol.88, No.14 (2014), 7715-7726
Abstract: The RV144 ALVAC/AIDSVax HIV-1 vaccine clinical trial showed an estimated vaccine efficacy of 31.2%. Viral genetic analysis identified a vaccine-induced site of immune pressure in the HIV-1 envelope (Env) variable region 2 (V2) focused on residue 169, which is included in the epitope recognized by vaccinee-derived V2 monoclonal antibodies. The ALVAC/AIDSVax vaccine induced antibody-dependent cellular cytotoxicity (ADCC) against the Env V2 and constant 1 (C1) regions. In the presence of low IgA Env antibody levels, plasma levels of ADCC activity correlated with lower risk of infection. In this study, we demonstrate that C1 and V2 monoclonal antibodies isolated from RV144 vaccinees synergized for neutralization, infectious virus capture, and ADCC. Importantly, synergy increased the HIV-1 ADCC activity of V2 monoclonal antibody CH58 at concentrations similar to that observed in plasma of RV144 vaccinees. These findings raise the hypothesis that synergy among vaccine-induced antibodies with different epitope specificities contributes to HIV-1 antiviral antibody responses and is important to induce for reduction in the risk of HIV-1 transmission. © 2014, American Society for Microbiology.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904113226&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/33160
ISSN: 10985514
0022538X
Appears in Collections:Scopus 2011-2015

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