Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33171
Title: Transcriptome analysis reveals pathogenicity and evolutionary history of the pathogenic oomycete Pythium insidiosum
Authors: Theerapong Krajaejun
Tassanee Lerksuthirat
Gagan Garg
Tassanee Lowhnoo
Wanta Yingyong
Rommanee Khositnithikul
Sithichoke Tangphatsornruang
Prapat Suriyaphol
Shoba Ranganathan
Thomas D. Sullivan
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Macquarie University
Yong Loo Lin School of Medicine
University of Wisconsin School of Medicine and Public Health
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2014
Citation: Fungal Biology. Vol.118, No.7 (2014), 640-653
Abstract: Oomycetes form a unique group of microorganisms that share hyphal morphology with fungi. Most of pathogenic oomycetes infect plants, while some species are capable of infecting animals. Pythium insidiosum is the only oomycete that can infect both humans and animals, and causes a life-threatening infectious disease, called 'pythiosis'. Controlling an infection caused by P. insidiosum is problematic because effective antimicrobial drugs are not available. Information on the biology and pathogenesis of P. insidiosum is limited. We generated a P. insidiosum transcriptome of 26735 unigenes, using the 454 sequencing platform. As adaptations to increased temperature inside human hosts are required for a successful pathogen, we generated P. insidiosum transcriptomes at 28°C and 37°C and identified 625 up-regulated and 449 down-regulated genes at 37°C. Comparing the proteomes of oomycetes, fungi, and parasites provided clues on the evolutionary history of P. insidiosum. Potential virulence factors of P. insidiosum, including putative effectors, were identified. Pythium insidiosum harbored an extensive repertoire of ~300 elicitin domain-containing proteins. The transcriptome, presented herein, provides an invaluable resource for exploring P. insidiosum's biology, pathogenesis, and evolution. © 2014 The British Mycological Society.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905216938&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/33171
ISSN: 18786146
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.