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dc.contributor.authorMarkus Hiltyen_US
dc.contributor.authorDaniel Wüthrichen_US
dc.contributor.authorSusannah J. Salteren_US
dc.contributor.authorHansjürg Engelen_US
dc.contributor.authorSamuel Campbellen_US
dc.contributor.authorRaquel Sá-Leãoen_US
dc.contributor.authorHermínia De Lencastreen_US
dc.contributor.authorPeter Hermansen_US
dc.contributor.authorEwa Sadowyen_US
dc.contributor.authorPaul Turneren_US
dc.contributor.authorClaire Chewapreechaen_US
dc.contributor.authorMathew Diggleen_US
dc.contributor.authorGerd Pluschkeen_US
dc.contributor.authorLesley McGeeen_US
dc.contributor.authorÖzgen Köseoʇlu Eseren_US
dc.contributor.authorDonald E. Lowen_US
dc.contributor.authorHeidi Smith-Vaughanen_US
dc.contributor.authorAndrea Endimianien_US
dc.contributor.authorMarianne Kü Fferen_US
dc.contributor.authorMélanie Dupasquieren_US
dc.contributor.authorEmmanuel Beaudoingen_US
dc.contributor.authorJohann Weberen_US
dc.contributor.authorRémy Bruggmannen_US
dc.contributor.authorWilliam P. Hanageen_US
dc.contributor.authorJulian Parkhillen_US
dc.contributor.authorLucy J. Hathawayen_US
dc.contributor.authorKathrin Mü Hlemannen_US
dc.contributor.authorStephen D. Bentleyen_US
dc.contributor.otherUniversity of Bernen_US
dc.contributor.otherUniversitatsSpital Bernen_US
dc.contributor.otherSwiss Institute of Bioinformaticsen_US
dc.contributor.otherWellcome Trust Sanger Instituteen_US
dc.contributor.otherInstituto de Tecnologia Quimica e Biologica - Univesidade Nova de Lisboaen_US
dc.contributor.otherRockefeller Universityen_US
dc.contributor.otherRadboud University Nijmegenen_US
dc.contributor.otherNational Medicines Institute, Warsawen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherQueen's Medical Centreen_US
dc.contributor.otherUniversitat Baselen_US
dc.contributor.otherNational Center for Immunization and Respiratory Diseasesen_US
dc.contributor.otherHacettepe Universitesien_US
dc.contributor.otherMount Sinai Hospital of University of Torontoen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.contributor.otherUniversitat Lausanne Schweizen_US
dc.contributor.otherHarvard School of Public Healthen_US
dc.contributor.otherUniversity of Cambridgeen_US
dc.date.accessioned2018-11-09T01:48:50Z-
dc.date.available2018-11-09T01:48:50Z-
dc.date.issued2014-01-01en_US
dc.identifier.citationGenome Biology and Evolution. Vol.6, No.12 (2014), 3281-3294en_US
dc.identifier.issn17596653en_US
dc.identifier.other2-s2.0-84933510790en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84933510790&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/33175-
dc.description.abstract© The Author(s) 2014. The surrounding capsule of Streptococcus pneumoniae has been identified as a major virulence factor and is targeted by pneumococcal conjugate vaccines (PCV). However, nonencapsulated S. pneumoniae (non-Ec-Sp) have also been isolated globally, mainly in carriage studies. It is unknown if non-Ec-Sp evolve sporadically, if they have high antibiotic nonsusceptiblity rates and a unique, specific gene content. Here, whole-genome sequencing of 131 non-Ec-Sp isolates sourced from 17 different locations around the world was performed. Results revealed a deep-branching classic lineage that is distinct from multiple sporadic lineages. The sporadic lineages clustered with a previously sequenced, global collection of encapsulated S. pneumoniae (Ec-Sp) isolates while the classic lineage is comprised mainly of the frequently identified multilocus sequences types (STs) ST344 (n = 39) and ST448 (n = 40). All ST344 and nine ST448 isolates had high nonsusceptiblity rates to β-lactams and other antimicrobials. Analysis of the accessory genome reveals that the classic non-Ec-Sp contained an increased number of mobile elements, than Ec-Sp and sporadic non-Ec-Sp. Performing adherence assays to human epithelial cells for selected classic and sporadic non-Ec-Sp revealed that the presence of a integrative conjugative element (ICE) results in increased adherence to human epithelial cells (P = 0.005). In contrast, sporadic non-Ec-Sp lacking the ICE had greater growth in vitro possibly resulting in improved fitness. In conclusion, non-Ec-Sp isolates from the classic lineage have evolved separately. They have spread globally, are well adapted to nasopharyngeal carriage and are able to coexist with Ec-Sp. Due to continued use of PCV, non-Ec-Sp may become more prevalent.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84933510790&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleGlobal phylogenomic analysis of nonencapsulated Streptococcus pneumoniae reveals a deep-branching classic lineage that is distinct from multiple sporadic lineagesen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1093/gbe/evu263en_US
Appears in Collections:Scopus 2011-2015

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