Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33198
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJee Young Kwonen_US
dc.contributor.authorPreeyaporn Koedrithen_US
dc.contributor.authorYoung Rok Seoen_US
dc.contributor.otherDongguk University, Seoulen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-11-09T01:49:32Z-
dc.date.available2018-11-09T01:49:32Z-
dc.date.issued2014-12-15en_US
dc.identifier.citationInternational Journal of Nanomedicine. Vol.9, (2014), 271-286en_US
dc.identifier.issn11782013en_US
dc.identifier.issn11769114en_US
dc.identifier.other2-s2.0-84938223264en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84938223264&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/33198-
dc.description.abstract© 2014 Kwon et al. Engineered nanoparticles (NPs) are widely used in many sectors, such as food, medicine, military, and sport, but their unique characteristics may cause deleterious health effects. Close attention is being paid to metal NP genotoxicity; however, NP genotoxic/carcinogenic effects and the underlying mechanisms remain to be elucidated. In this review, we address some metal and metal oxide NPs of interest and current genotoxicity tests in vitro and in vivo. Metal NPs can cause DNA damage such as chromosomal aberrations, DNA strand breaks, oxidative DNA damage, and mutations. We also discuss several parameters that may affect genotoxic response, including physicochemical properties, widely used assays/end point tests, and experimental conditions. Although potential biomarkers of nanogenotoxicity or carcinogenicity are suggested, inconsistent findings in the literature render results inconclusive due to a variety of factors. Advantages and limitations related to different methods for investigating genotoxicity are described, and future directions and recommendations for better understanding genotoxic potential are addressed.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84938223264&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectChemistryen_US
dc.subjectMaterials Scienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCurrent investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: Carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitationsen_US
dc.typeReviewen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.2147/IJN.S57918en_US
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.