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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33223
Title: Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways
Authors: Anorut Jenwitheesuk
Chutikorn Nopparat
Sujira Mukda
Prapimpun Wongchitrat
Piyarat Govitrapong
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Chemistry;Computer Science
Issue Date: 22-Sep-2014
Citation: International Journal of Molecular Sciences. Vol.15, No.9 (2014), 16848-16884
Abstract: © 2014 by the authors; licensee MDPI, Basel, Switzerland. Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907882606&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/33223
ISSN: 14220067
16616596
Appears in Collections:Scopus 2011-2015

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