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Title: Lack of genotoxic potential of ZnO nanoparticles in in vitro and in vivo tests
Authors: Jee Young Kwon
Seung Young Lee
Preeyaporn Koedrith
Jong Yun Lee
Kyoung Min Kim
Jae Min Oh
Sung Ik Yang
Meyoung Kon Kim
Jong Kwon Lee
Jayoung Jeong
Eun Ho Maeng
Beam Jun Lee
Young Rok Seo
Dongguk University, Seoul
Kyung Hee University
Korea Testing and Research Institute
Chungbuk National University
Mahidol University. Faculty of Environment and Resource Studies
Yonsei University
Korea University, College of Medicine
Ministry of Food and Drug Safety (MFDS)
Keywords: Biochemistry, Genetics and Molecular Biology;Environmental Science
Issue Date: 1-Feb-2014
Citation: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. Vol.761, (2014), 1-9
Abstract: The industrial application of nanotechnology, particularly using zinc oxide (ZnO), has grown rapidly, including products such as cosmetics, food, rubber, paints, and plastics. However, despite increasing population exposure to ZnO, its potential genotoxicity remains controversial. The biological effects of nanoparticles depend on their physicochemical properties. Preparations with well-defined physico-chemical properties and standardized test methods are required for assessing the genotoxicity of nanoparticles. In this study, we have evaluated the genotoxicity of four kinds of ZnO nanoparticles: 20. nm and 70. nm size, positively or negatively charged. Four different genotoxicity tests (bacterial mutagenicity assay, in vitro chromosomal aberration test, in vivo comet assay, and in vivo micronucleus test, were conducted, following Organization for Economic Cooperation and Development (OECD) test guidelines with good laboratory practice (GLP) procedures. No statistically significant differences from the solvent controls were observed. These results suggest that surface-modified ZnO nanoparticles do not induce genotoxicity in in vitro or in vivo test systems. © 2014 Elsevier B.V.
ISSN: 18793592
Appears in Collections:Scopus 2011-2015

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