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dc.contributor.authorLegesse Adaneen_US
dc.contributor.authorShweta Bhagaten_US
dc.contributor.authorMinhajul Arfeenen_US
dc.contributor.authorSonam Bhatiaen_US
dc.contributor.authorRachada Sirawarapornen_US
dc.contributor.authorWorachart Sirawarapornen_US
dc.contributor.authorAsit K. Chakrabortien_US
dc.contributor.authorPrasad V. Bharatamen_US
dc.contributor.otherNational Institute of Pharmaceutical Education and Research India, Mohalien_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-11-09T01:54:50Z-
dc.date.available2018-11-09T01:54:50Z-
dc.date.issued2014-01-15en_US
dc.identifier.citationBioorganic and Medicinal Chemistry Letters. Vol.24, No.2 (2014), 613-617en_US
dc.identifier.issn14643405en_US
dc.identifier.issn0960894Xen_US
dc.identifier.other2-s2.0-84891846323en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891846323&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/33316-
dc.description.abstractA new class of compounds based on S-benzylated guanylthiourea has been designed as potential PfDHFR inhibitors using computer aided methods (molecular electrostatic potential, molecular docking). Several compounds in this class have been synthesized starting from guanylthiourea and alkyl bromides. In vitro studies showed that two compounds from this class are active with the IC50value of 100 μM and 400 nM. © 2013 Elsevier Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891846323&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDesign and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzymeen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.bmcl.2013.12.009en_US
Appears in Collections:Scopus 2011-2015

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