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dc.contributor.authorTheerawut Klangjareonchaien_US
dc.contributor.authorHataikarn Nimitphongen_US
dc.contributor.authorSunee Saetungen_US
dc.contributor.authorNuttapimon Bhirommuangen_US
dc.contributor.authorRattanapan Samittarucksaen_US
dc.contributor.authorSuwannee Chanprasertyothinen_US
dc.contributor.authorRattana Sudatipen_US
dc.contributor.authorBoonsong Ongphiphadhanakulen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationInternational Journal of Endocrinology. Vol.2014, (2014)en_US
dc.description.abstract© 2014 Theerawut Klangjareonchai et al. Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis. Taken together, this suggests a probable network among fat, bone, and muscle that may influence health outcomes. The aims of this study were to investigate the relationship of circulating sclerostin and irisin and their association with adiposity (assessed by body mass index (BMI)). Materials/Methods. A cross-sectional study included 98 adults with impaired fasting glucose and/or impaired glucose tolerance. 75 gm OGTT was performed in all subjects. Fasting plasma samples were obtained for glycated hemoglobin, calcium, creatinine, serum sclerostin and irisin. Results. Circulating irisin and sclerostin were highly correlated (r = - 0.4; P < 0.001). After controlling for age, gender, and BMI, irisin was significantly related to sclerostin (P < 0.001). Multivariate linear regression analysis demonstrated that circulating sclerostin (β = - 0.45; P < 0.05) and irisin (β = - 0.46; P < 0.05) were negatively associated with BMI, independent of age in males. In females, no relationship of sclerostin or irisin to BMI was found. Conclusions. Circulating irisin and sclerostin are highly related. Interventions targeting irisin could affect sclerostin and vice versa.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleCirculating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetesen_US
Appears in Collections:Scopus 2011-2015

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