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Title: Toward one-pot lipase-catalyzed synthesis of poly(e-caprolactone) particles in aqueous dispersion
Authors: Pranee Inprakhon
Pabhangkon Panlawan
Thunyarat Pongtharankul
Emmanuelle Marie
Lars O. Wiemann
Alain Durand
Volker Sieber
Mahidol University
Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB
CNRS Centre National de la Recherche Scientifique
Université de Lorraine
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Chemistry;Physics and Astronomy
Issue Date: 1-Jan-2014
Citation: Colloids and Surfaces B: Biointerfaces. Vol.113, (2014), 254-260
Abstract: The preparation of polyester particles using enzyme-catalyzed (lipase from Candida antarctica B, CALB) ring-opening polymerization of e-caprolactone (e-CL) in aqueous dispersion was demonstrated for the first time. Immobilization of CALB enabled a significant increase of the number-average degree of polymerization of e-CL oligomers (up to 38) as compared to dissolved CALB (8 at the maximum). The nature and amount of lipase, as well as the nature of the support material were identified as key parameters controlling ring-opening polymerization of e-CL in aqueous dispersion. In addition, the involvement of solubilized monomers in polymerization elementary reactions was demonstrated and the consequences on oligomers average length were detailed. An overall mechanism of lipase-catalyzed e-CL polymerization in aqueous dispersion taking into account the colloidal nature of reaction medium was proposed on the basis of experimental results. © 2013 Elsevier B.V.
ISSN: 18734367
Appears in Collections:Scopus 2011-2015

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