Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: The association between perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant Thai women
Authors: Natthinee Charatcharoenwitthaya
Boonsong Ongphiphadhanakul
Elizabeth N. Pearce
Charintip Somprasit
Athita Chanthasenanont
Xuemei He
Laor Chailurkit
Lewis E. Braverman
Faculty of Medicine, Thammasat University
Mahidol University
Boston University School of Medicine
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2014
Citation: Journal of Clinical Endocrinology and Metabolism. Vol.99, No.7 (2014), 2365-2371
Abstract: Context: Thyroid hormone is critical for fetal neurodevelopment. Perchlorate and thiocyanate decrease thyroidal iodine uptake by competitively inhibiting the sodium/iodide symporter. It is clear that perchlorate and thiocyanate anions can influence thyroid function. However, as pollutants in the environment, their impact is conflicting. Objective: The objective was to determine the effects of environmental perchlorate and/or thiocyanate exposure on thyroid function in first-trimester pregnant women. Design and Patients: A cross-sectional study was conducted in 200 pregnant Thai women with a gestational age of 14 weeks or less. Measures: Urinary iodide, perchlorate, thiocyanate, and serum thyroid function tests were measured. Results: The women were aged 28.6 ± 6.1 years and the mean gestational age was 9.6 ± 2.7 weeks. Median urinary iodide, perchlorate, and thiocyanate concentrations were 153.5 μg/L, 1.9 μg/L, and 510.5 μg/L, respectively. Using Spearman's rank correlation analyses, there were positive correlations between serum TSH and urine perchlorate to creatinine (r = 0.20, P = .005) and TSH and thiocyanate to creatinine ratios (r = 0.22, P = .001). There were negative correlations between free T4and the perchlorate to creatinine ratio (r = -0.18, P = .01) and free T4and the thiocyanate to creatinine ratio (r = -0.19, P = .008). In multivariate analyses adjusting for log thiocyanate to creatinine ratio, log iodide to creatinine ratio, and gestational age, log perchlorate to creatinine ratio was positively associated with log TSH (P = .002) and inversely associated with log free T4(P = .002). Log thiocyanate to creatinine ratio was a significant positive predictor of log TSH (P = .02) in women with a urine iodide level of less than 100 μg/L. Conclusions: Low-level environmental exposure to perchlorate and thiocyanate is common in Thailand. Low-level exposure to perchlorate is positively associated with TSH and negatively associated with free T4in first-trimester pregnantwomenusing multivariate analyses. In multivariate analyses, thiocyanate exposure is also positively associated with TSH in a subgroup of pregnant women with low iodine excretion. Copyright © 2014 by the Endocrine Society.
ISSN: 19457197
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.