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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33499
Title: Anodal transcranial direct current stimulation of the motor cortex induces opposite modulation of reciprocal inhibition in wrist extensor and flexor
Authors: Alexandra Lackmy-Vallée
Wanalee Klomjai
Bernard Bussel
Rose Katz
Nicolas Roche
Sorbonne Universite
Mahidol University
Universite de Versailles Saint-Quentin-en-Yvelines
Hopital Universitaire Pitie Salpetriere
APHP Hôpital
Keywords: Biochemistry, Genetics and Molecular Biology;Neuroscience
Issue Date: 1-Jan-2014
Citation: Journal of Neurophysiology. Vol.112, No.6 (2014), 1505-1515
Abstract: © 2014 the American Physiological Society. Transcranial direct current stimulation (tDCS) is used as a noninvasive tool to modulate brain excitability in humans. Recently, several studies have demonstrated that tDCS applied over the motor cortex also modulates spinal neural network excitability and therefore can be used to explore the corticospinal control acting on spinal neurons. Previously, we showed that reciprocal inhibition directed to wrist flexor motoneurons is enhanced during contralateral anodal tDCS, but it is likely that the corticospinal control acting on spinal networks controlling wrist flexors and extensors is not similar. The primary aim of the study was to explore the effects of anodal tDCS on reciprocal inhibition directed to wrist extensor motoneurons. To further examine the supraspinal control acting on the reciprocal inhibition between wrist flexors and extensors, we also explored the effects of the tDCS applied to the ipsilateral hand motor area. In healthy volunteers, we tested the effects induced by sham and anodal tDCS on reciprocal inhibition pathways innervating wrist muscles. Reciprocal inhibition directed from flexor to extensor muscles and the reverse situation, i.e., reciprocal inhibition, directed from extensors to flexors were studied in parallel with the H reflex technique. Our main finding was that contralateral anodal tDCS induces opposing effects on reciprocal inhibition: it decreases reciprocal inhibition directed from flexors to extensors, but it increases reciprocal inhibition directed from extensors to flexors. The functional result of these opposite effects on reciprocal inhibition seems to favor wrist extension excitability, suggesting an asymmetric descending control onto the interneurons that mediate reciprocal inhibition.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84907255116&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/33499
ISSN: 15221598
00223077
Appears in Collections:Scopus 2011-2015

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