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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33515
Title: Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
Authors: Kaye N. Ballantyne
Arwin Ralf
Rachid Aboukhalid
Niaz M. Achakzai
Maria J. Anjos
Qasim Ayub
Jože Balažic
Jack Ballantyne
David J. Ballard
Burkhard Berger
Cecilia Bobillo
Mehdi Bouabdellah
Helen Burri
Tomas Capal
Stefano Caratti
Jorge Cárdenas
François Cartault
Elizeu F. Carvalho
Monica Carvalho
Baowen Cheng
Michael D. Coble
David Comas
Daniel Corach
Maria E. D'Amato
Sean Davison
Peter de Knijff
Maria Corazon A. De Ungria
Ronny Decorte
Tadeusz Dobosz
Berit M. Dupuy
Samir Elmrghni
Mateusz Gliwiński
Sara C. Gomes
Laurens Grol
Cordula Haas
Erin Hanson
Jürgen Henke
Lotte Henke
Fabiola Herrera-Rodríguez
Carolyn R. Hill
Gunilla Holmlund
Katsuya Honda
Uta Dorothee Immel
Shota Inokuchi
Mark A. Jobling
Mahmoud Kaddura
Jong S. Kim
Soon H. Kim
Wook Kim
Turi E. King
Eva Klausriegler
Daniel Kling
Lejla Kovačević
Leda Kovatsi
Paweł Krajewski
Sergey Kravchenko
Maarten H.D. Larmuseau
Eun Young Lee
Ruediger Lessig
Ludmila A. Livshits
Damir Marjanović
Marek Minarik
Natsuko Mizuno
Helena Moreira
Niels Morling
Meeta Mukherjee
Patrick Munier
Javaregowda Nagaraju
Franz Neuhuber
Shengjie Nie
Premlaphat Nilasitsataporn
Takeki Nishi
Hye H. Oh
Jill Olofsson
Valerio Onofri
Jukka U. Palo
Horolma Pamjav
Walther Parson
Michal Petlach
Christopher Phillips
Rafal Ploski
Samayamantri P.R. Prasad
Dragan Primorac
Gludhug A. Purnomo
Josephine Purps
Hector Rangel-Villalobos
Krzysztof Reogonekbała
Budsaba Rerkamnuaychoke
Danel Rey Gonzalez
Carlo Robino
Lutz Roewer
Alexandra Rosa
Antti Sajantila
Erasmus University Medical Center
Office of the Chief Forensic Scientist
Mohammed V University in Rabat
University of the Punjab, Lahore
Instituto Nacional de Medicina Legal
Wellcome Trust Sanger Institute
University of Ljubljana Faculty of Medicine
University of Central Florida
King's College London
Medizinische Universitat Innsbruck
Universidad de Buenos Aires
University of Zurich
Institute of Criminalistics Prague
Universita degli Studi di Torino
Universidad de Santiago de Compostela
Site Centre Hospitalier Felix Guyon
Universidade do Estado do Rio de Janeiro
Institute of the Forensic Sciences
National Institute of Standards and Technology
Universitat Pompeu Fabra Barcelona
University of the Western Cape
Leiden University Medical Center - LUMC
University of the Philippines Diliman
KU Leuven
Wroclaw Medical University
Norwegian Institute of Public Health
University of Benghazi
Gdanski Uniwersytet Medyczny
Universidade da Madeira
Netherlands Forensic Institute - NFI
Institut für Blutgruppenforschung LGC GmbH
Sección de Bioquímica del Departamento de Ciencias Forenses
Linkopings universitet
University of Tsukuba
Martin-Universitat Halle-Wittenberg
National Research Institute of Police Science
University of Leicester
Supreme Prosecutors' Office
National Forensic Service, Republic of Korea
Dankook University
Universitat Salzburg
Institute for Genetic Engineering and Biotechnology
Aristotle University of Thessaloniki
Medical University of Warsaw
Institute of Molecular Biology and Genetics National Academy of Sciences of Ukraine
Yonsei University College of Medicine
Genomac Research Institute
Universidade de Aveiro
Kobenhavns Universitet
Central Forensic Science Laboratory India
Centre for DNA Fingerprinting and Diagnostics India
Kunming Medical University
Sci. Crime Detect. Div.
Universita Politecnica delle Marche
Helsingin Yliopisto
Universität Budapest
Pennsylvania State University
University of New Haven
University of Split
Eijkman Institute for Molecular Biology
Charité – Universitätsmedizin Berlin
Universidad de Guadalajara
Mahidol University
University of North Texas Health Science Center
University of Cologne
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2014
Citation: Human Mutation. Vol.35, No.8 (2014), 1021-1032
Abstract: Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. The value of 13 rapidly-mutating (RM) Y-STRs for differentiating male individuals is investigated in 14,644 related and unrelated men sampled from 111 worldwide populations. Over 99% of the 12,272 unrelated men were completely individualized. Of the 2,378 father-son pairs, 27% were separated. Figure: blue lines represent Y-STR haplotypes shared between population pairs in a subset of 7,784 males from 65 populations. Almost all shared haplotypes defined by conventional 17 Yfiler Y-STRs (above) are resolved with the 13 RM Y-STRs (below). © 2014 Wiley Periodicals, Inc.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904433303&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/33515
ISSN: 10981004
10597794
Appears in Collections:Scopus 2011-2015

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