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Title: Photo-cured PMMA/PEI core/shell nanoparticles surface-modified with Gd-DTPA for T1 MR imaging
Authors: Montri Ratanajanchai
Don Haeng Lee
Panya Sunintaboon
Su Geun Yang
Utah-Inha DDS and Advanced Therapeutics
Mahidol University
Inha University, College of Medicine
Keywords: Chemical Engineering;Materials Science
Issue Date: 1-Feb-2014
Citation: Journal of Colloid and Interface Science. Vol.415, (2014), 70-76
Abstract: Herein, we introduced amine-functionalized core-shell nanoparticles (Polymethyl methacrylate/Polyethyleneimine; PMMA/PEI) with surface primary amines (3.15×105groups/particle) and uniform size distribution (150-200nm) that were prepared by one-step photo-induced emulsion polymerization. Further PEI-surface was modified with diethylenetriamine pentaacetic acid (DTPA) and introduced with Gd(III). The modified particles possessing DTPA can entrap a high content of Gd(III) ions of over 5.5×104Gd/particle with stable chelation (no release of free Gd) at least 7h. The Gd-DTPA-conjugated core-shell nanoparticles (PMMA/PEI-DTPA-Gd NPs) enhanced the MRI intensity more than Primovist (a commercial hepatic contrast agent). Moreover, the PMMA/PEI-DTPA-Gd NPs showed non-cytotoxicity up to 250μM in normal liver cells. Thus, in vitro data suggested the PMMA/PEI-DTPA-Gd NPs is promising delivery system as a superior MRI contrast agent, especially for hepatic lesion targeted MR imaging. © 2013 Elsevier Inc.
ISSN: 10957103
Appears in Collections:Scopus 2011-2015

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