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Title: Quantitative study of BSA coating silica nanoparticle
Authors: Duangkamon Baowan
Volkhard Helms
Mahidol University
Universitat des Saarlandes
Keywords: Chemistry;Mathematics
Issue Date: 1-Jan-2014
Citation: Journal of Mathematical Chemistry. Vol.53, No.1 (2014), 29-40
Abstract: © 2014, Springer International Publishing Switzerland. The loading of biomolecules on nanoparticles might be thought of as a first step to design a cargo in drug delivery system. Here, we study a quantity of bovine serum albumin (BSA) surrounding the silica nanoparticle. The silica nanoparticle is modeled as a perfect sphere whereas the BSA is represented by an ellipsoid. On utilizing a continuous approximation, the electrostatic and van der Waals interactions can be analytically expressed. Further, a number of BSA molecules coating on the nanoparticles of various sizes can be simply determined as a function of the protein ring radius. Our finding is in a good agreement found in experiment and this can be a guide to evaluate the number of protein on other type of spherical nanoparticles.
ISSN: 02599791
Appears in Collections:Scopus 2011-2015

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