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Title: Appalachian mountaintop mining particulate matter induces neoplastic transformation of human bronchial epithelial cells and promotes tumor formation
Authors: Sudjit Luanpitpong
Michael Chen
Travis Knuckles
Sijin Wen
Juhua Luo
Emily Ellis
Michael Hendryx
Yon Rojanasakul
West Virginia University
West Virginia University Robert C. Byrd Health Sciences Center
Mahidol University
Indiana University
Keywords: Chemistry;Environmental Science
Issue Date: 1-Jan-2014
Citation: Environmental Science and Technology. Vol.48, No.21 (2014), 12912-12919
Abstract: © 2014 American Chemical Society. Epidemiological studies suggest that living near mountaintop coal mining (MTM) activities is one of the contributing factors for high lung cancer incidence. The purpose of this study was to investigate the long-term carcinogenic potential of MTM particulate matter (PMMTM) exposure on human bronchial epithelial cells. Our results show that chronic exposure (3 months) to noncytotoxic, physiological relevant concentration (1 μg/mL) of PMMTM, but not control particle PMCON, induced neoplastic transformation, accelerated cell proliferation, and enhanced cell migration of the exposed lung cells. Xenograft transplantation of the PMMTM-exposed cells in mice caused no apparent tumor formation, but promoted tumor growth of human lung carcinoma H460 cells, suggesting the tumor-promoting effect of PMMTM. Chronic exposure to the main inorganic chemical constituent of PMMTM, molybdenum but not silica, similarly induced cell transformation and tumor promotion, suggesting the contribution of molybdenum, at least in part, in the PMMTM effects. These results provide new evidence for the carcinogenic potential of PMMTM and support further risk assessment and implementation of exposure control for PMMTM.
ISSN: 15205851
Appears in Collections:Scopus 2011-2015

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