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dc.contributor.authorSudjit Luanpitpongen_US
dc.contributor.authorMichael Chenen_US
dc.contributor.authorTravis Knucklesen_US
dc.contributor.authorSijin Wenen_US
dc.contributor.authorJuhua Luoen_US
dc.contributor.authorEmily Ellisen_US
dc.contributor.authorMichael Hendryxen_US
dc.contributor.authorYon Rojanasakulen_US
dc.contributor.otherWest Virginia Universityen_US
dc.contributor.otherWest Virginia University Robert C. Byrd Health Sciences Centeren_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherIndiana Universityen_US
dc.identifier.citationEnvironmental Science and Technology. Vol.48, No.21 (2014), 12912-12919en_US
dc.description.abstract© 2014 American Chemical Society. Epidemiological studies suggest that living near mountaintop coal mining (MTM) activities is one of the contributing factors for high lung cancer incidence. The purpose of this study was to investigate the long-term carcinogenic potential of MTM particulate matter (PMMTM) exposure on human bronchial epithelial cells. Our results show that chronic exposure (3 months) to noncytotoxic, physiological relevant concentration (1 μg/mL) of PMMTM, but not control particle PMCON, induced neoplastic transformation, accelerated cell proliferation, and enhanced cell migration of the exposed lung cells. Xenograft transplantation of the PMMTM-exposed cells in mice caused no apparent tumor formation, but promoted tumor growth of human lung carcinoma H460 cells, suggesting the tumor-promoting effect of PMMTM. Chronic exposure to the main inorganic chemical constituent of PMMTM, molybdenum but not silica, similarly induced cell transformation and tumor promotion, suggesting the contribution of molybdenum, at least in part, in the PMMTM effects. These results provide new evidence for the carcinogenic potential of PMMTM and support further risk assessment and implementation of exposure control for PMMTM.en_US
dc.rightsMahidol Universityen_US
dc.subjectEnvironmental Scienceen_US
dc.titleAppalachian mountaintop mining particulate matter induces neoplastic transformation of human bronchial epithelial cells and promotes tumor formationen_US
Appears in Collections:Scopus 2011-2015

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