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Title: [6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release
Authors: Thanaporn Chantarodsakun
Thammasit Vongsetskul
Kulachart Jangpatarapongsa
Patoomratana Tuchinda
Sukanda Uamsiri
Chuthamas Bamrungcharoen
Supeecha Kumkate
Pakorn Opaprakasit
Pramuan Tangboriboonrat
Mahidol University
Sirindhorn International Institute of Technology, Thammasat University
Keywords: Chemistry;Materials Science;Physics and Astronomy
Issue Date: 1-Jan-2014
Citation: Polymer Bulletin. Vol.71, No.12 (2014), 3163-3176
Abstract: © 2014, Springer-Verlag Berlin Heidelberg. [6]-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that [6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded [6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of [6]-gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %.
ISSN: 01700839
Appears in Collections:Scopus 2011-2015

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