Please use this identifier to cite or link to this item:
|Title:||-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release|
Sirindhorn International Institute of Technology, Thammasat University
|Keywords:||Chemistry;Materials Science;Physics and Astronomy|
|Citation:||Polymer Bulletin. Vol.71, No.12 (2014), 3163-3176|
|Abstract:||© 2014, Springer-Verlag Berlin Heidelberg. -Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that -gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded -gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of -gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %.|
|Appears in Collections:||Scopus 2011-2015|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.