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dc.contributor.authorChariya Kaewsanehaen_US
dc.contributor.authorPramuan Tangboriboonraten_US
dc.contributor.authorAbdelhamid Elaissarien_US
dc.contributor.authorDuangporn Polpanichen_US
dc.contributor.authorKulachart Jangpatarapongsaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherLaboratoire d'Automatique et de Génie des Procédésen_US
dc.contributor.otherThailand National Nanotechnology Centeren_US
dc.identifier.citationAdvanced Materials Research. Vol.893, (2014), 329-336en_US
dc.description.abstractSubmicron magnetic polymeric particle (MPP) and/or Janus magnetic polymeric particle (JMPP) were successfully prepared via the miniemulsion polymerization of styrene (St)/acrylic acid (AA) monomers consisting of superparamagnetic iron oxide nanoparticles (IONPs) coated with oleic acid. Since the particle nucleation occurs primarily within the monomer droplet, not only the size of particle could be controlled at the beginning but also its morphology was manipulated by using different types of initiator. The MPPs with homogeneous distribution of IONPs (41%) in P(St-DVB-AA) were obtained with using potassium persulfate (KPS) as initiator and divinyl benzene (DVB) as crosslinking agent. To obtain anisotropic JMPP, an oil-soluble initiator 2,2'- azobis(2-isobutyronitrile) was used instead. The controllable phase separation between P(St-AA) and the encapsulated IONPs caused the stable spherical Janus particles containing IOPNs (15%) located on one side of polymer particle. Both MPPs and JMPPs could be easily separated by an external magnet. The MPPs were functionalized with chitosan (CS) acting as spacer and then chemical immobilized with fluorescein isothiocyanate (FITC) to produce fluorescent-MPPs. When applying as imaging device for cancer cells labeling i.e., HeLa, cells, results showed that MPPs/CSFITC could be located inside cells with low cytotoxicity. © (2014) Trans Tech Publications, Switzerland.en_US
dc.rightsMahidol Universityen_US
dc.titleHybrid fluorescent-magnetic polymeric particles for biomedical applicationsen_US
dc.typeConference Paperen_US
Appears in Collections:Scopus 2011-2015

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