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Title: Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
Authors: Nicholas J. White
Elizabeth A. Ashley
Judith Recht
Michael J. Delves
Andrea Ruecker
Frank M. Smithuis
Alice C. Eziefula
Teun Bousema
Chris Drakeley
Kesinee Chotivanich
Mallika Imwong
Sasithon Pukrittayakamee
Jetsumon Prachumsri
Cindy Chu
Chiara Andolina
Germana Bancone
Tran T. Hien
Mayfong Mayxay
Walter R.J. Taylor
Lorenz Von Seidlein
Ric N. Price
Karen I. Barnes
Abdoulaye Djimdé
Feiko Ter Kuile
Roly Gosling
Ingrid Chen
Mehul J. Dhorda
Kasia Stepniewska
Philippe Guérin
Charles J. Woodrow
Arjen M. Dondorp
Nicholas P.J. Day
Francois H. Nosten
Mahidol University
Nuffield Department of Clinical Medicine
Imperial College London
Myanmar Oxford Clinical Research Unit
London School of Hygiene & Tropical Medicine
Mahosot Hospital
Menzies School of Health Research
University of Cape Town
University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
Liverpool School of Tropical Medicine
UCSF Global Health Sciences
Churchill Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 9-Dec-2014
Citation: Malaria Journal. Vol.13, No.1 (2014)
Abstract: © 2014 White et al. Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.
ISSN: 14752875
Appears in Collections:Scopus 2011-2015

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