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Title: Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum
Authors: Fan Yang
Erping Long
Juhua Wen
Lei Cao
Chengcheng Zhu
Huanxin Hu
Ying Ruan
Kamolnetr Okanurak
Huiling Hu
Xiaoxia Wei
Xiangyun Yang
Chaofan Wang
Limei Zhang
Xiaoying Wang
Pengyu Ji
Huanqin Zheng
Zhongdao Wu
Zhiyue Lv
Sun Yat-Sen University, Zhongshan School of Medicine
Sun Yat-Sen University
Hunan University of Chinese Medicine
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 29-Aug-2014
Citation: Parasites and Vectors. Vol.7, No.1 (2014)
Abstract: © 2014 Yang et al.; licensee BioMed Central Ltd. Background: Schistosomiasis japonicum remains a considerable economic and public health concern in China, the Philippines and Indonesia. Currently available measures to control the unique intermediate host Oncomelania hupensis are frequently associated with severe side effects. Previous studies have demonstrated that linalool-rich extracts from various plants exhibited promising biological activities including cytotoxic, anti-microbial and anti-parasitic properties. Methods. We identified the components of leaf extracts from Cinnamomum camphora by gas chromatography coupled to mass spectrometry (GC-MS) and investigated molluscicidal and larvicidal effects of linalool against O. hupensis and Schistosoma japonicium. The ultrastructural alterations in gills, salivary gland, stomach and hepatopancreas of snails were observed under the light microscope and transmission electron microscope, and lesions to tegument of cercaria were examined under a light microscope and fluorescence microscope. We then evaluated the effects of linalool on skin penetration and migration of schistosomula and adult survival by measurement of worm burden and egg counts in Balb/C mice infected with linalool-treated cercariae. Results: In the present work, 44 components were identified from the leaf extracts of C. camphora, of which linalool was the most abundant constituent. Linalool exhibited the striking molluscicidal and larvicidal effects with LC50= 0.25 mg/L for O. hupensis and LC50= 0.07 mg/L for cercaria of S. japonicium. After exposure to linalool, damage to the gills and hepatopancreas of the snails, and to the tegument and body-tail joint of cercariae was apparent. In addition, linalool markedly reduced the recovered schistosomulum from mouse skin after challenge infection, and therefore decreased the worm burden in infected animals, but not fecundity of female adults of the parasite. Conclusions: Our findings indicated that linalool might be a novel chemotherapeutic agent against S. japonicium and the snail intermediate host.
ISSN: 17563305
Appears in Collections:Scopus 2011-2015

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