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Title: Dengue virus infection induces expansion of a CD14<sup>+</sup>CD16<sup>+</sup>monocyte population that stimulates plasmablast differentiation
Authors: Marcin Kwissa
Helder I. Nakaya
Nattawat Onlamoon
Jens Wrammert
Francois Villinger
Guey Chuen Perng
Sutee Yoksan
Kovit Pattanapanyasat
Kulkanya Chokephaibulkit
Rafi Ahmed
Bali Pulendran
Emory University
Mahidol University
National Cheng Kung University
Keywords: Immunology and Microbiology
Issue Date: 9-Jul-2014
Citation: Cell Host and Microbe. Vol.16, No.1 (2014), 115-127
Abstract: Dengue virus (DENV) infection induces the expansion of plasmablasts, which produce antibodies that can neutralize DENV but also enhance disease upon secondary infection with another DENV serotype. To understand how these immune responses are generated, we used a systems biological approach to analyze immune responses to dengue in humans. Transcriptomic analysis of whole blood revealed that genes encoding proinflammatory mediators and type I interferon-related proteins were associated with high DENV levels during initial symptomatic disease. Additionally, CD14+CD16+monocytes increased in the blood. Similarly, in a nonhuman primate model, DENV infection boosted CD14+CD16+monocyte numbers in the blood and lymph nodes. Upon DENV infection in vitro, monocytes upregulated CD16 and mediated differentiation of resting B cells to plasmablasts as well as immunoglobulin G (IgG) and IgM secretion. These findings provide a detailed picture of innate responses to dengue and highlight a role for CD14+CD16+monocytes in promoting plasmablast differentiation and anti-DENV antibody responses. © 2014 Elsevier Inc.
ISSN: 19346069
Appears in Collections:Scopus 2011-2015

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