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Title: Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques
Authors: Monica Vaccari
Claudio Fenizia
Zhong Min Ma
Anna Hryniewicz
Adriano Boasso
Melvin N. Doster
Christopher J. Miller
Niklas Lindegardh
Joel Tarning
Alan L. Landay
Gene M. Shearer
Genoveffa Franchini
National Cancer Institute
UC Davis California National Primate Research Center
Mahidol University
Nuffield Department of Clinical Medicine
Rush University Medical Center
Uniwersytet Medyczny w Bialymstoku
Chelsea and Westminster Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Apr-2014
Citation: AIDS Research and Human Retroviruses. Vol.30, No.4 (2014), 355-362
Abstract: Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down-regulation of innate acute responses to the virus within a few weeks of infection and results in limited pathology. Chloroquine (CQ) has been used in the treatment or prevention of malaria and has recently been shown to cause a decrease of immune activation and CD4 cell loss in HIV-infected individuals treated with antiretroviral therapy. Here, we treated Rhesus macaques with CQ during the acute phase of SIVmac251infection with the intent to decrease viral-induced immune activation and possibly limit disease progression. Contrary to what was expected, CQ treatment resulted in a temporary increased expression of interferon (IFN)-stimulating genes and it worsened the recovery of CD4+T cells in the blood. Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy. © 2014 Mary Ann Liebert Inc.
ISSN: 19318405
Appears in Collections:Scopus 2011-2015

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