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dc.contributor.authorMonica Vaccarien_US
dc.contributor.authorClaudio Feniziaen_US
dc.contributor.authorZhong Min Maen_US
dc.contributor.authorAnna Hryniewiczen_US
dc.contributor.authorAdriano Boassoen_US
dc.contributor.authorMelvin N. Dosteren_US
dc.contributor.authorChristopher J. Milleren_US
dc.contributor.authorNiklas Lindegardhen_US
dc.contributor.authorJoel Tarningen_US
dc.contributor.authorAlan L. Landayen_US
dc.contributor.authorGene M. Sheareren_US
dc.contributor.authorGenoveffa Franchinien_US
dc.contributor.otherNational Cancer Instituteen_US
dc.contributor.otherUC Davis California National Primate Research Centeren_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherRush University Medical Centeren_US
dc.contributor.otherUniwersytet Medyczny w Bialymstokuen_US
dc.contributor.otherChelsea and Westminster Hospitalen_US
dc.identifier.citationAIDS Research and Human Retroviruses. Vol.30, No.4 (2014), 355-362en_US
dc.description.abstractSimian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down-regulation of innate acute responses to the virus within a few weeks of infection and results in limited pathology. Chloroquine (CQ) has been used in the treatment or prevention of malaria and has recently been shown to cause a decrease of immune activation and CD4 cell loss in HIV-infected individuals treated with antiretroviral therapy. Here, we treated Rhesus macaques with CQ during the acute phase of SIVmac251infection with the intent to decrease viral-induced immune activation and possibly limit disease progression. Contrary to what was expected, CQ treatment resulted in a temporary increased expression of interferon (IFN)-stimulating genes and it worsened the recovery of CD4+T cells in the blood. Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy. © 2014 Mary Ann Liebert Inc.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleTransient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaquesen_US
Appears in Collections:Scopus 2011-2015

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