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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/33997
Title: Characterization of human immunodeficiency virus type 1 CRF01_AE env genes derived from recently infected Thai individuals
Authors: Nithinart Chaitaveep
Piraporn Utachee
Shota Nakamura
Thippawan Chuenchitra
Pattama Ekpo
Naokazu Takeda
Kovit Pattanapanyasat
Masanori Kameoka
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand-Japan Research Collaboration Center on Emerging
Osaka University
Kobe University School of Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Feb-2014
Citation: Microbes and Infection. Vol.16, No.2 (2014), 142-152
Abstract: Transmitted/founder virus is responsible for the establishment of human immunodeficiency virus type 1 (HIV-1) infection and induces primary anti-HIV-1 immune responses; therefore, it is important to study the viral population to understand the early events of HIV-1 infection. We amplified HIV-1 env genes from sera derived from recently infected Thai individuals, and established envelope glycoproteins (Env)-recombinant viruses. Generated Env-recombinant viruses were tested for their neutralization susceptibility to neutralizing human monoclonal antibodies (NHMAbs) and entry inhibitors, as well as being subjected to genotypic analysis. Most recombinant viruses were susceptible to neutralization by NHMAbs to Env gp41, whereas approximately one-third of the recombinant viruses were susceptible to a NHMAb against the CD4 binding site of gp120. In addition, all env genes were classified into CRF01_AE genes and showed low genetic divergence. Taken together with our previous studies on CRF01_AE env genes derived from chronically infected Thai individuals, these results suggested that the immunological and genetic characteristics of CRF01_AE Env derived from recently infected Thai individuals were different from those derived from chronically infected individuals. © 2013 Institut Pasteur.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84894971811&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/33997
ISSN: 1769714X
12864579
Appears in Collections:Scopus 2011-2015

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