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dc.contributor.authorNithinart Chaitaveepen_US
dc.contributor.authorPiraporn Utacheeen_US
dc.contributor.authorShota Nakamuraen_US
dc.contributor.authorThippawan Chuenchitraen_US
dc.contributor.authorPattama Ekpoen_US
dc.contributor.authorNaokazu Takedaen_US
dc.contributor.authorKovit Pattanapanyasaten_US
dc.contributor.authorMasanori Kameokaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherThailand-Japan Research Collaboration Center on Emergingen_US
dc.contributor.otherOsaka Universityen_US
dc.contributor.otherKobe University School of Medicineen_US
dc.identifier.citationMicrobes and Infection. Vol.16, No.2 (2014), 142-152en_US
dc.description.abstractTransmitted/founder virus is responsible for the establishment of human immunodeficiency virus type 1 (HIV-1) infection and induces primary anti-HIV-1 immune responses; therefore, it is important to study the viral population to understand the early events of HIV-1 infection. We amplified HIV-1 env genes from sera derived from recently infected Thai individuals, and established envelope glycoproteins (Env)-recombinant viruses. Generated Env-recombinant viruses were tested for their neutralization susceptibility to neutralizing human monoclonal antibodies (NHMAbs) and entry inhibitors, as well as being subjected to genotypic analysis. Most recombinant viruses were susceptible to neutralization by NHMAbs to Env gp41, whereas approximately one-third of the recombinant viruses were susceptible to a NHMAb against the CD4 binding site of gp120. In addition, all env genes were classified into CRF01_AE genes and showed low genetic divergence. Taken together with our previous studies on CRF01_AE env genes derived from chronically infected Thai individuals, these results suggested that the immunological and genetic characteristics of CRF01_AE Env derived from recently infected Thai individuals were different from those derived from chronically infected individuals. © 2013 Institut Pasteur.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleCharacterization of human immunodeficiency virus type 1 CRF01_AE env genes derived from recently infected Thai individualsen_US
Appears in Collections:Scopus 2011-2015

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