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Title: Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release
Authors: Promsin Masrinoul
Orapim Puiprom
Atsushi Tanaka
Miwa Kuwahara
Panjaporn Chaichana
Kazuyoshi Ikuta
Pongrama Ramasoota
Tamaki Okabayashi
Mahidol University
Osaka University
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2014
Citation: Virology. Vol.464-465, No.1 (2014), 111-117
Abstract: Chikungunya virus (CHIKV) causes an acute clinical illness characterized by sudden high fever, intense joint pain, and skin rash. Recent outbreaks of chikungunya disease in Africa and Asia are a major public health concern; however, there is currently no effective licensed vaccine or specific treatment. This study reported the development of a mouse monoclonal antibody (MAb), CK47, which recognizes domain III within the viral envelope 1 protein and inhibited the viral release process, thereby preventing the production of progeny virus. The MAb had no effect on virus entry and replication processes. Thus, CK47 may be a useful tool for studying the mechanisms underlying CHIKV release and may show potential as a therapeutic agent. © 2014 Elsevier Inc.
ISSN: 10960341
Appears in Collections:Scopus 2011-2015

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