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dc.contributor.authorChonlaphat Sukasemen_US
dc.contributor.authorApichaya Puangpetchen_US
dc.contributor.authorSadeep Medhasien_US
dc.contributor.authorWichittra Tassaneeyakulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherKhon Kaen Univeresityen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.identifier.citationAsian Pacific Journal of Allergy and Immunology. Vol.32, No.2 (2014), 111-123en_US
dc.description.abstractDrug hypersensitivity reactions affect many patients leading to a variety of clinical manifestations, mainly the cutaneous adverse reactions ranging from milder skin reactions to severe cutaneous adverse reactions (SCARs). Hypersensitivity reactions are unpredictable and are thought to have an underlying genetic etiology, as suggested by case reports. With the scientific knowledge of pharmacogenomics and the evidence based on the genomic testing, it is possible to identify genetic predisposing factors for these serious adverse reactions and personalize drug therapy. The most significant genetic associations have been identified in the major histocompatibility complex (MHC) genes encoded for human leukocyte antigens (HLA) alleles. Drugs associated with hypersensitivity reactions with strong genetic predisposing factors include abacavir, nevirapine, carbamazepine, and allopurinol. In this review, strong genetic associations of drug-induced SCARs are highlighted so as to improve drug safety and help to select optimal drugs for individual patients. Further investigation, however, is essential for the characterization of other genes involved in the hypersensitivity reactions with the use of several genetic strategies and technologies.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePharmacogenomics of drug-induced hypersensitivity reactions: Challenges, opportunities and clinical implementationen_US
Appears in Collections:Scopus 2011-2015

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